Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair–Deficient Colorectal Cancer
Published in Cancer Immunology Research, 2019
Tumours with a high number of mutations, in particular those with DNA repair defects such as Microsatellite Instability (MSI), are FDA-approved for immunotherapy; yet not all patients respond. This study aimed at refining our understanding of the link between TMB and immunotherapy response. To this end, we conducted an exploratory analysis of a patient who did not respond to immunotherapy despite having an MSI colorectal tumour.
Recommended citation: Gurjao, C. et al. Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair–Deficient Colorectal Cancer. Cancer Immunol Res 7, 1230–1236 (2019). http://carinogurjao.github.io/files/CIR_2019.pdf